Lea Grinberg, USA

FTLD pathology and copathology


Neuropathological examination remains the gold standard for diagnosing neurodegenerative conditions, including frontotemporal lobar degeneration (FTLD). Thanks to recent methodological advances and the increase in well-characterized clinicopathological cohorts, our knowledge of FTLD neuropathology has advanced rapidly, necessitating updates to diagnostic criteria and nomenclature. This presentation will delve into the latest developments in FTLD neuropathology and explore emerging insights into the role of copathology, including recently describe neuropathological entities. The discussion will cover the frequency of copathologies, their impact on disease progression, and the resulting clinical outcomes. Additionally, it will highlight clinicopathological correlations, providing a deeper understanding of how copathologies influence the clinical manifestations and trajectory of FTLD.


Lea T. Grinberg, MD, PhD, is the John Douglas French Alzheimer’s Foundation Endowed Professor and  Professor of Neurology and Pathology at UCSF. As co-leader of the UCSF Memory and Aging Center Neuropathology Core, she performs brain autopsies and contributes to international workgroups on neurodegenerative conditions. Her research focuses on the early stages of neurodegenerative diseases. She has a particularly frontotemporal lobar degeneration and tauopathies. Dr. Grinberg has over 320 peer-reviewed publications and leads several NIH and foundation-funded projects.